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Large molecule specific assay operation: recommendation for best practices and harmonization from the global bioanalysis consortium harmonization team. Two-step selective formation of three disulfide bridges in the synthesis of the C-terminal epidermal growth factor-like domain in human blood coagulation factor IX. A monomer can only perform one reaction, and a dimer is therefore interesting in explaining how VKORC1 accomplishes both reactions. The software package is publicly available at https://github.com/namsyvo/RandAL.

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