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Seventy-six patients with stage IB-IIB cervical cancer treated with radical hysterectomy with pelvic lymph node metastases and/or vascular invasion randomly received adjuvant chemotherapy (400 mg/m2 carboplatin, and 30 mg bleomycin), standardized external pelvic radiation therapy, or no further treatment. Geophysics from triton to the deep blue sea: new quake forecast: north by northwest. Guanidino compounds and aliphatic monoamines in acute and chronic renal failure This unexpected dual role of FoxO1 in promoting insulin sensitivity and lipid synthesis in addition to glucose production has the potential to explain the peculiar admixture of insulin resistance and sensitivity that is commonly observed in the metabolic syndrome. A new trial design was developed that allows the bioavailability of thyroid hormone preparations to be determined without the use of radiolabelled substances.

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Detection of submicroscopic lymph node metastases with polymerase chain reaction in patients with malignant melanoma. Tuberous xanthomata and coronary artery disease associated with hyperlipidemia. The age and the insulin sensitivity of the subject should be taken into account when interpreting the results. Phaeochromocytoma and paraganglioma: next-generation sequencing and evolving Mendelian syndromes.

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Those results enable us to state positively that the methods in use at present in the laboratories are precise and give highly reproducible results. The dynamics of structural changes in the liver in experimental dyslipoproteinemia (DLP) and its correction was studied. The incidence of hepatitis delta virus infection in chronic liver diseases in Hungary. Study data were obtained from a population-based longitudinal study, the Taiwan Longitudinal Study of Aging (TLSA), with a nationally representative sample of nearly-old and old Taiwanese.

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The objective of this study was to explore the relationship between oxidative molecular damage and the aging process by determining whether such damage is associated with the rate of aging, using the adult housefly as the experimental organism. The maximum flexion angle at the MCP joint increased from 18.8 degrees (pre-block) to 33.7 degrees (post-block), and maximum flexion angle at the IP joint decreased from 42.6 degrees (pre-block) to 18.8 degrees (post-block). The prophylaxis method of occurring ligature fistula in patients injured in Chernobyl Nuclear Power disaster Data suggest that both neurotrophic and hypothalamic-pituitary-adrenocortical (HPA) systems are involved in the pathophysiology of depression.

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A beta-sheet segment running from about V19 to V23 (capital letters refer to amino acids in the single-letter notation) is folded onto a beta-sheet segment running from R28 to N32 and joined by a chain reversal from E24 to D27. POA-derived cortical interneurons take a superficial path and avoid the developing striatum (Str) when they migrate to their target region. Evidence is accumulating that interactions between different cell types are of paramount importance for CNS function, for example, release of the excitatory transmitter glutamate from neurons and its preferential uptake into astrocytes. Neck reexploration for primary hyperparathyroidism has a lower success rate and greater morbidity than initial exploration because of scarring and distortion of tissue planes and the possibility of a parathyroid neoplasm located in an ectopic or unusual position.

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A point mutation of proline 308 in diphtheria toxin B chain inhibits membrane translocation of toxin conjugates. Hybridization of RNA or DNA-derived samples to DNA chips allows us to monitor expression of mRNAs or the occurrence of polymorphisms in genomic DNA. By contrast, after weaning, the duration of grooming movements of long displacement directed to the fur, genital area, and body scratching were significantly increased.

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Resting membrane potential and potassium currents in cultured parasympathetic neurones from rat intracardiac ganglia. Examination with biomicroscopy revealed protruding orbital masses superotemporally in both eyes, with the right lesion being larger than the left. Transpedicular biopsy was performed on 18 patients (nine open and nine percutaneous).

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Knowledge of the epidemiology of Aspergillus species is necessary for the development of strategies to prevent invasive aspergillosis. melanogaster hemoglobin 1 (product of the glob1 gene) displays heme endogenous hexacoordination in both the ferrous and ferric states. Increase of length and weight during the first 6 months of life, and height at 1 and 5.5 years of age were investigated in 132 children of epileptic mothers (the study group) and 103 control children born after 37 completed gestational weeks.

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The natural history of untreated asymptomatic primary hyperparathyroidism (PHPT) remains incompletely understood. Percutaneous transluminal coronary angioplasty: clinical and quality of life outcomes one year later. The patient underwent surgical removal of the gallbladder neoplasm and showed disease recurrence with pulmonary and liver metastases.

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Chest pain, elevated troponin and moderate coronary stenosis - a clinical puzzle solved by cardiac magnetic resonance Here, we used resting-state fMRI in lightly anesthetized macaque monkeys to measure the intrinsic functional connectivity of the prefrontal cortex. These efforts have evolved from offsetting the impact of hypoxia on radiotherapy with oxygen-mimetic radiosensitizers to using hypoxia as a means to selectively target tumors. Containing a detailed account of the Shoushi Li (see text for symbol) as well as a comparative study of Chinese and Islamic calendrical systems, these treatises have drawn the attention not only of Seki but of modern historians.

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Two neonates with cardiovascular symptoms associated with intracranial AVM were initially considered to have ductal-dependent congenital heart disease. To increase MSM sample representativeness, we used Respondent Driven Sampling (RDS) for the first time in Argentina. To determine the association between dyspnea at entry into the PAQUID cohort and 13-year mortality, taking into consideration BMI and other mortality-related factors. The aim of this study was to compare the pain perception and side effects during and after endovenous laser ablation with a 1470 nm diode laser using cold or room temperature tumescence anesthesia. We report the development of severe oral infection with HSV type 1 in a 34 year old woman with type 1 diabetes mellitus and end stage renal disease (ESRD) following cadaveric renal transplantation at the Western General Hospital, Edinburgh.

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Their possible differential use with regard to the different epileptic syndromes and to the specific epileptologic history of the patient are examined. Transmission electron microscopy of GroEL, GroES, and the symmetrical GroEL/ES complex. To describe experience with bronchial artery embolization (BAE) in a cohort of patients with cancer. What does psychoanalysis have to contribute to the understanding of character?

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Some drugs, such as histamine H2-receptor antagonists, are relatively safe but are overprescribed. Sexual functioning was assessed using the Female Sexual Functioning Index (FSFI) and the International Index of Erectile Function (IIEF). Novel double heterozygous mutations in MEFV and NLRP3 genes in a patient with familial Mediterranean fever. Retinoids are a group of naturally occurring and synthetic compounds with vitamin A-like biological activity. A change in the method of quality control in our orthopaedic trauma unit allowed us the opportunity to study if the quality of operative outcomes had changed as a result.

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Mutations in the p53 gene are frequently found in many human cancers and are localized in the highly conserved region of the gene. At the earliest stages of cell atrophy, hydrolase-positive lysosomes accumulated at the basal pole and then massively throughout the perikarya and proximal and proximal dendrites of affected pyramidal neurons in Alzheimer prefrontal cortex and hippocampus, far exceeding the changes of normal aging. Comprehensive analysis of long non-coding RNAs in ovarian cancer reveals global patterns and targeted DNA amplification.

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The distribution and the frequency of occurrence of nine types of gut endocrine cells were revealed using immunohistochemical methods in eight portions from the gastrointestinal tract of the chicken (Gallus gallus var domestica). Pharmacokinetic modeling and simulation of the data derived from these studies are then used to inform future decisions regarding drug administration, including dosage and schedule. This reduces hydrodissection-related complications such as posterior capsule rupture, anterior hyaloid membrane tear, extension of zonule fracture, and pseudoexpulsive hemorrhage. Both tumors were found to be aneuploid by flow cytometric DNA study.

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Leprechaunism is characterized by severe intrauterine growth retardation, elfin-like face, relatively large hands, feet and genitalia and abnormal skin with hypertrichosis, acanthosis nigricans and low subcutaneous fat. Histologically, a hyperplastic and inflammatory reaction was present in the synovium at 7 days PI.

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Piperacillin/tazobactam MICs were 16- to 128-fold higher for mutant strains than for their parent strain. Ischaemic preconditioning (IPC) as a cardioprotective strategy has not fulfilled it clinical potential, primarily because of the need to intervene before the index ischaemic event, which is impossible to predict in patients presenting with an acute myocardial infarction (AMI). Relatively low serum mannose-binding lectin (MBL) levels and MBL genetic polymorphisms have been implicated as high risk factors for neonatal sepsis.

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Quantitative assessment of association between rs1801133 polymorphism and susceptibility to stroke. Our investigation of the mediating effect of depression on the relationship between disability and suicidal ideation revealed that depression was either a complete (disability related to cognition, self-care, getting along with others, and life activities) or partial (disability related to participation) mediator. Our data show that high leukotoxicity correlates with an enhanced risk for the progression of AL.

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In addition, an alternate and more efficient one-step method to make a 3/5/6 tricyclic ring system using the Robinson annulation method has been developed toward the generation of a library of compounds around this skeleton. Those photographs that were placed in the same age category by two-thirds or more of the students were used as a pool for the second phase of the study. Boron neutron capture therapy: boron biodistribution and pharmacokinetics of Na2B12H11SH in patients with glioblastoma. It appears that daily administration of rifampicin may be useful in treating multibacillary patients in whom reduction in the BI is slower than expected.

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Small workers of head width 0.5-1.8 mm, those generally engaged in duties inside the nest, contain chiefly 4-methyl-3-heptanone. Bovids are among the most frequently utilized paleoenvironmental indicators, but little is known about the habitat preferences of extinct taxa.

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Lower proficiency in English or French also did not appear to heighten the risk. A rehabilitation classification system is introduced as a means to identify rehabilitation needs of children with HIV. Epidemiology of burns in Singapore children--an 11-year study of 2288 patients. monniera extract (BME) against crackers smoke induced neuronal and physiological changes via modulating inducible nitric oxide synthase (iNOS) and hemeoxygenase-1 (HO-1) expression in rats.

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Mean IgM levels were significantly higher in acute patients than in controls. Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats. The comparison of the calculated internal forces with results of in-vitro studies indicates a possible health risk for persons with a low vertebral strength during repetitive exposures to moderate transient whole-body vibrations. Orofacial pain increases mRNA level for galanin in the trigeminal nucleus caudalis of the rat. We also discovered a well-developed immune system with a considerable number of lineage-specific antigen-presentation genes for adaptive immunity as well as expansion of the tripartite motif-containing C-type lectin and butyrophilin genes for innate immunity and expression of antibacterial peptides.

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Here we use a combination of theory and a phylogenetic comparative analysis of 191 pathogenic bacterial species to show that bacteria use cooperative secretions that modify their environment to extend their host range and infect multiple host species. INTERACTION BETWEEN CRYSTALLINE PENICILLIN AND HUMAN PLASMA PROTEINS.

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Clinical findings and results of operative treatment in ilioinguinal nerve entrapment syndrome. High-sensitivity assays that accurately measure levels of CRP have been proposed for use in risk assessment for CVD and as a prognostic marker after an acute event, although the pathogenic and clinical significance of these associations is controversial. We describe a new species of Phrynopus from the humid grassland of Distrito de Comas, Provincia Concepcion, Department of Junin. For 3-walled periodontal osseous defects, guided tissue regeneration was superior to conventional periodontal flap surgery. We suggest that the RAS/cAMP pathway is defective in germinating conidia of Aspergillus amino acid auxotrophs and that this is responsible for suppressing DNA repair and conferring sensitivity to oxidative stress and heat shock.

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Cell therapy: a 21st-century hope for treating cardiovascular disease--what do the next 5 years hold? Every day the animals were exposed to experimental conditions characteristic of 7.000 m of high above sea level (first experimental group) and every odd day (second experimental group). A measure of general practice level socioeconomic deprivation can be used to explore the association between deprivation and other practice characteristics. This study used TEE to analyze the variations in the PVF pattern after successful valvar dilatation in MS patients.

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Improved method for retinotopy constrained source estimation of visual-evoked responses. Modulation of calcium oxalate crystallization by linear aspartic acid-rich peptides.

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Comparison of the efficacy and tolerance of a garlic preparation vs. Electroencephalogram (EEG) and clinical features clearly differentiate cerebral anoxic attacks from epileptic seizures. These data suggest that MMC might be a better agent for HIPEC delivery than Oxaliplatin in patients with CRCPC, favorable histologies and low burden of disease (PSDSS I/II) undergoing complete cytoreduction. Biopsy results of left ventricular myocardium confirmed toxic myocarditis due to ingestion of hydrofluoric acid.

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Because gibberellins (GAs) increase internode length by affecting both cell division and cell length, we tested if SLs stimulate internode elongation by affecting GA metabolism or signaling. Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome. The paper explores the institutions required for successful local government intervention. The possible selection bias due to the use of different series of controls in case-control studies has been analysed in the Norwegian part of a joint national case-control study in Sweden and Norway of oral contraceptive (OC) use and breast cancer in young women. To evaluate the feasibility of simplified MAG-ESD using permanent magnets.

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Here, we examined potential mechanisms through which gain-of-function (GOF) p53 proteins can induce motility. For diagnostic purposes, differential spinal anesthesia with lidocaine and morphine was performed, with evoked potential monitoring used to evaluate the intensity of spinal anesthetic block.

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A series of single electron-transfer (SET) reactions on a naphthyl thioether have shown that the reductive cleavage mechanism changes at low temperatures and this selectivity is proved using an electrochemical analysis that mimics the SET reaction conditions. Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method. Forty SLE patients (mean age 33 yrs) and 33 normal volunteers were submitted to BSI. However, the mechanism involved in Pg LPS-induced VCAM-1 production in endothelial cells remains unclear. Contractile activity was measured by means of chronically implanted force transducers, and changes in pH of the perfusate through the HP were monitored simultaneously.

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Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles. Fractionation of female extracts demonstrated that the activity was exclusively located in the nonpolar fraction. The production of epidermal growth factor and polypeptides similar to it in the intestinal mucosa of rats in 1,2-dimethylhydrazine-induced carcinogenesis and compensatory regeneration

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Characterization of distinct aspects of the neonatal immune response is defining novel approaches to enhance host defense to prevent and/or treat staphylococcal infection in this vulnerable population. One hundred and seventy-eight adults aged 19-89 years with dyspeptic symptoms suggesting gastroduodenal pathology were enrolled in the study. Influence of landscape factors and management decisions on spatial and temporal patterns of the transmission of chronic wasting disease transmission in white-tailed deer. The model described in this article provides a process to assist teachers in the successful selection, implementation, and assessment of SRS technology in the classroom.

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High resolution diffusion tensor imaging of human nerves in forearm. Recent studies in murine models have cast doubt on the importance of JAK2 in CML maintenance. elegans dosage compensation is linked to the loss of developmental plasticity. Fibrinogen Montreal: a novel missense mutation (Aa D496N) associated with hypofibrinogenaemia.

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This cell line offers a useful tool for analyzing the pathogenesis and pathophysiology of amylase-producing lung cancers. These observations suggest that the pharmacokinetics of ISDN administered s.c. Kinetics of the dichroic reorientation of phytochrome during photoconversion inMougeotia.

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These results indicate that polymorphisms within SP-A loci may be associated with otitis media in white infants. intestinalis in Sudan, where standardized food and drinking water hygiene precautions could not be implemented. Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting.

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Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. These data offer evidence to suggest that the epidemic of thyroid cancer is due to increased detection of a reservoir of previously occult disease. Analysis of BAP1 protein expression using immunohistochemistry may serve as a rapid and cost-effective means of identifying uveal melanoma patients with aggressive disease, who can then be managed appropriately. Immunohistochemical localization of GAP-43 in the developing hamster retinofugal pathway.

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A retrospective review on the benefits and complications of self-expandable metallic stent (SEMS) insertion through flexible bronchoscopy for the palliative treatment of upper airway obstruction in University Malaya Medical Centre was performed. The great progress in research in this field paved the way to study principal mechanisms of cellular organization and differentiation in these bacteria. Poly(maleic anhydride-alt-hexen-1)(poly(MA-alt-H-1)) has been synthesized by radical polymerization and characterized by DSC, FT-IR, acid number determination, viscometric and NMR methods. These results demonstrate that corticosteroids are necessary for sensitization of the dopaminergic system to occur and that they most probably act through the type II (or glucocorticoid) receptor subtype.

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Transthoracic atrial and TEE LAA strain and strain rate, which are quantitative measures of atrial function, are reduced after cardioversion, and recover subsequently. However, the optimal strategy to identify patients at high non-SCD risk is unclear and further research is needed. In this study, we investigated the role of extracellular nucleotides in intestinal epithelial migratory responses. Date extraction Key themes were identified and a narrative analysis was undertaken. Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C.

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Increased awareness by surgeons to the coexistence of inguinal hernia with peritoneal neoplasm and the need for a surgical repair is raised. Although adult survivors prioritize fertility and parenthood, this issue remains unexplored among adolescent males. Microvascular transplants are increasingly being used to improve facial contour in patients with this condition.